Cib1 Monoclonal Antibody for Rat(Rattus norvegicus) | EIAab.comCib1 Monoclonal Antibody for Rat(Rattus norvegicus)

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Cib1 (Gene name),

Calcium and integrin-binding protein 1 (Protein name ), CIB1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Cib1(Cib;Kip;Prkdcip);

Protein name:

Calcium and integrin-binding protein 1(CIB);

Alternative:

DNA-PKcs-interacting protein;Calmyrin;Kinase-interacting protein(KIP);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with the heterodimeric integrin alpha-IIb/beta3 (By similarity). Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK (By similarity). Interacts with PSEN2 (By similarity). Interacts with MYO1C (By similarity). Interacts (via C-terminus) with F8 (By similarity). Interacts with NBR1 (via C-terminus) (By similarity). Interacts with FEZ1 (via C-terminus) (By similarity). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation (By similarity). Interacts with IFI6 (By similarity). Interacts with BCL2 (By similarity). Interacts with ITPR3; in a calcium dependent manner (By similarity). Interacts with PTK2 (By similarity). Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2 (By similarity). Interacts with TAS1R2 (via C-terminus); this interaction is independent of the myristoylation state of CIB1.

Function:

May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain (By similarity). Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes) (By similarity). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways (By similarity). May play a role in regulation of apoptosis (By similarity). Interacts with and up-regulates PTK2 activity (By similarity). Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.

Subcellular Location:

Membrane Lipid-anchor Cytoplasm Nucleus Cell projection filopodium Apical cell membrane Localizes to the perinuclear region in the presence of NBR1 (By similarity). Colocalizes with TAS1R2 in apical regions of taste receptor cells.

Protein Attributes:

Sequence length:

191

Sequence:

50:

100:

150:

191:

QLIDNILEES | DIDRDGTINL | SEFQHVISRS | PDFASSFKIV | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.833

String:

Q9R010

SMR:

Q9R010

Pfam:

PF13499

KEGG:

rno:81823

Uniprot:

Q9R010

FOR

ELISA Kit for Rat CIB

Cat.:

E1394h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Rat CIB

Cat.:

E1394b

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Packing:

96T

ELISA Kit for Rat CIB

Cat.:

E1394m

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Packing:

96T

ELISA Kit for Rat CIB

Cat.:

E1394r

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Packing:

96T

CLIA Kit for Rat CIB

Cat.:

U1394r

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MSDS:

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Packing:

96T

CLIA Kit for Rat CIB

Cat.:

U1394m

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MSDS:

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Packing:

96T

CLIA Kit for Rat CIB

Cat.:

U1394h

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MSDS:

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Packing:

96T

CLIA Kit for Rat CIB

Cat.:

U1394b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat CIB

Cat.:

P1394Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat CIB

Cat.:

P1394Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat CIB

Cat.:

P1394Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat CIB

Protein for Rat CIB

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity."
Kauselmann G. , Weiler M. , Wulff P. , Jessberger S. , Konietzko U. , Scafidi J. , Staubli U. , Bereiter-Hahn J. , Strebhardt K. , Kuhl D.
EMBO J.18:5528-5539(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Ovary.
3.

"Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo."
Hennigs J.K. , Burhenne N. , Staehler F. , Winnig M. , Walter B. , Meyerhof W. , Schmale H.
J. Neurochem.106:2249-2262(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TAS1R2;MYRISTOYLATION;SUBCELLULAR LOCATION
4.

"CIB1 is a regulator of pathological cardiac hypertrophy."
Heineke J. , Auger-Messier M. , Correll R.N. , Xu J. , Benard M.J. , Yuan W. , Drexler H. , Parise L.V. , Molkentin J.D.
Nat. Med.16:872-879(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth."
Sobczak A. , Debowska K. , Blazejczyk M. , Kreutz M.R. , Kuznicki J. , Wojda U.
Biochim. Biophys. Acta1813:1025-1037(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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